Vioxx is used for pain relief
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Vioxx

VIOXX can provide 24-hour relief of osteoarthritis pain to help you enjoy everyday life again, controlling the pain that prevents you from doing simple things like walking or bending down.

ROFECOXIB - ORAL
COMMON BRAND NAME(S): Viox
USES: This medication is a nonsteroidal anti-inflammatory drug (NSAID) which relieves pain and swelling (inflammation). It is used to treat arthritis, menstrual pain or other acute pain. This drug works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.

(ROFECOXIB)

Uses
Vioxx is a nonsteroidal anti-inflammatory drug (NSAID) known as a COX-2 inhibitor used to relieve the symptoms of osteoarthritis and to treat pain and menstrual discomfort.

Before using Vioxx
Some medicines or medical conditions may interact with Vioxx. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking. Additional monitoring of your dose or condition may be needed if you are taking an ace inhibitor, anticoagulant, furosemide, lithium, methotrexate, rifampin, thiazide diuretics, or warfarin. Inform your doctor of any other medical conditions including aspirin-sensitive asthma, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about Vioxx.

Vioxx Directions
The usual dose of Vioxx for acute pain syndromes and menstrual cramps (primary dysmenorrhea) is 50 mg once daily for no longer than 5 days. The usual dose of Vioxx for treatment of osteoarthritis is 12.5 mg daily although some patients may benefit from 25 mg daily. The maximum daily dose should not exceed 25 mg. Vioxx may be taken on an empty stomach or with food.

Vioxx Storage
STORE Vioxx at room temperature at 70 to 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light.

Vioxx Miss a dose
If you miss a dose of Vioxx, and you are taking 1 dose daily, take the missed dose if you remember the same day. Skip the missed dose if you do not remember until the next day. DO NOT take 2 doses at once.

Vioxx Precautions
Do not take Vioxx if you have had severe allergic reaction to aspirin or any medicine containing aspirin or to a nonsteroidal anti-inflammatory drug (such as Feldene, Motrin, Naprosyn, Clinoril). A severe reaction includes a severe rash, hives, breathing difficulties, or dizziness. If you have a question about whether you are allergic to Vioxx or if a certain medicine is a nonsteroidal anti-inflammatory drug, contact your doctor or pharmacist. If you experience difficulty breathing; tightness of chest; swelling of eyelids, face, or lips; or if you develop a rash or hives, tell your doctor immediately. Do not take any more doses of Vioxx unless your doctor tells you to do so. DO NOT exceed the recommended dose or take Vioxx for longer than prescribed without checking with your doctor. Keep ALL doctor and laboratory appointments while you are using Vioxx.

Vioxx Alcohol warning
If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take Vioxx or other pain relievers/fever reducers. Vioxx may cause stomach bleeding.

Before a new medicine
Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes any medicines that contain ibuprofen, naproxen, or ketoprofen.

Vioxx For women
If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Vioxx during pregnancy. It is unknown if Vioxx is excreted in breast milk. DO NOT breast feed while taking Vioxx.

Vioxx Side effects
Side effects that may occur while taking Vioxx include weakness or nausea. If they continue or are bothersome, check with your doctor.

Call your doctor
Check in with your doctor immediately if you experience itching or skin rash, swelling of the feet or ankles, unexpected weight gain, vomiting material that looks like coffee grounds, or blood in stool or vomit.

Contact your doctor
Contact your doctor immediately if you experience swelling of hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; hoarseness; flu-like symptoms; sluggishness; yellowing of the skin or eyes; stomach pain; dark urine or pale stools; or unusual fatigue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Vioxx Notes
DO NOT share Vioxx with others for whom it was not prescribed. DO NOT use Vioxx for other health conditions. Keep this product out of the reach of children. If using Vioxx for an extended period of time, obtain refills before your supply runs out.

Rifampin: Co- administration of VIOXX with rifampin 600 mg daily, a potent inducer of hepatic metabolism, produced an approximate 50% decrease in rofecoxib plasma concentrations. Therefore, a starting daily dose of 25 mg of VIOXX should be considered for the treatment of osteoarthritis when VIOXX is co- administered with potent inducers of hepatic metabolism.

Warfarin: Prothrombin time (measured as I.R. increased in both single and multiple dose cross- over studies in healthy individuals receiving both warfarin and rofecoxib. In a 21- day multiple- dose study in healthy individuals stabilized on warfarin (2 to 8.5 mg daily), administration of rofecoxib 25 mg QD was associated with mean increases in INR of approximately 8% (range of INR on warfarin alone, 1.1 to 2.2; range of INR on warfarin plus rofecoxib, 1.2 to 2.4). Somewhat greater mean increases in INR of approximately 11% (range of maximum INR on warfarin alone, 1.5 to 2.7; range of maximum INR on warfarin plus rofecoxib, 1.6 to 4.4) were also seen in a single dose PK screening study using a 30- mg dose of warfarin and 50 mg of rofecoxib. Standard monitoring of INR values should be conducted when therapy with VIOXX is initiated or changed, particularly in the first few days, in patients receiving warfarin or similar agents.