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Famvir ( Famciclovir )

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FAMVIR (famciclovir) is a prescription oral antiviral medication that is indicated for treatment of recurrent genital herpes, suppression of recurrent genital herpes, and treatment of recurrent herpes simplex virus infections (genital herpes and cold sores) in HIV-infected patients.

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Famvir

Types of Treatment
After the initial outbreak* of genital herpes, FAMVIR can be prescribed in one of three ways:

  • Episodic treatment - your doctor treats an outbreak of genital herpes as it occurs. The usual dose of FAMVIR is one 125-mg pill, twice a day, for 5 days.†

  • Suppressive treatment — if you have frequent or severe outbreaks, you take one 250-mg pill, twice a day, for up to 1 year†‡ to suppress the genital herpes virus and help to prevent outbreaks.

  • Patients with HIV - FAMVIR is the only prescription oral antiviral therapy indicated for treating genital or orolabial herpes in people infected with HIV. In patients with herpes simplex and HIV, the dose of FAMVIR is 500 mg, twice a day, for 7 days.†

FAMVIR can be taken with or without food.

When discussing treatment options with your doctor, be sure to discuss your lifestyle, how you feel about outbreaks, the pain and severity of your symptoms, and the frequency of your outbreaks. Be sure to talk with your doctor about the type of treatment (episodic or suppressive) that would be most appropriate for you.

For episodic and suppressive treatment, always take your medicine as prescribed by your doctor. If you are taking any other prescription or over-the-counter medications, please be sure to tell your doctor. No medication has been proven to prevent the transmission of genital herpes. It's important to know that FAMVIR will not prevent the spread of genital herpes to others. During an outbreak, you must avoid sexual contact, and use a condom in between outbreaks.

Efficacy of FAMVIR

  • Episodic Treatment
    One clinical study showed that episodic treatment with FAMVIR significantly relieved all of the symptoms of a genital herpes outbreak. For many people, the duration of the symptoms associated with genital herpes, pain, burning, itching, and tenderness, was reduced. These same people also experienced a faster healing of sores compared to those taking a sugar pill.

  • Suppressive Treatment
    Many people on twice-daily suppressive therapy with FAMVIR may go almost a year without experiencing an outbreak.

Side Effects and Other Important Information
FAMVIR should not be taken by patients with known hypersensitivity to the product, its components, and DENAVIR® (penciclovir cream).

FAMVIR has no clinically significant interactions with cimetidine, allopurinol, theophylline, digoxin, or zidovudine (AZT).

Concurrent use of FAMVIR with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.

FAMVIR does not contain any dyes.

FAMVIR (famciclovir) is not for everyone. In clinical studies with FAMVIR, the most commonly reported side effects included headache, nausea, and diarrhea. Ask your doctor if FAMVIR is right for you.† If you have kidney problems, your doctor will determine if FAMVIR is appropriate, and if so, what the right dose is for you. See the full Prescribing Information for more information about FAMVIR.

* The efficacy of FAMVIR has not been established for the treatment of an initial outbreak of genital herpes infection.

 If you have impaired kidney function, your doctor will determine the appropriate dose for you.

 The safety and efficacy of FAMVIR therapy beyond 1 year of treatment have not been established.

No antiviral has been proven to prevent the transmission of genital herpes.

There is no cure for genital herpes.

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Is FAMVIR new?

No. FAMVIR has been prescribed by doctors to millions of patients all over the world.

What is new about FAMVIR?

FAMVIR can now be dosed in just one day. What this means is that you now have the power to stop or shorten a recurrent genital herpes outbreak with just a single day of treatment.

When do I take new Single-Day FAMVIR?

Take Single-Day FAMVIR as soon as you feel a genital herpes outbreak coming on. Although each person is different, common early symptoms may include pain, burning, itching, tingling, or tenderness. This stage of the outbreak is called the prodrome—a warning that a full-blown outbreak (which could include redness, bumps, blisters, and sores) may be coming. Many people feel these early warning signs or symptoms. Learning what your individual warning symptoms are can help you identify when an outbreak may be coming on. In the clinical trial, Single-Day FAMVIR was taken within 6 hours of either symptom onset or lesion appearance.

Why is it important for me to take Single-Day FAMVIR when I first feel an outbreak starting?

When you first start feeling the symptoms of an outbreak, the herpes virus is already actively reproducing. Starting Single-Day FAMVIR at this critical time can stop the virus from reproducing. If you can stop the virus during this time, you may be able to stop a full-blown outbreak.

What kind of results might I expect from new Single-Day FAMVIR?

In a clinical study of new Single-Day FAMVIR, many patients were able to

Stop or shorten an outbreak

Shorten the duration of symptoms, including pain, buring, itching, tingling, and tenderness

How do I take new Single-Day FAMVIR?

Take Single-Day FAMVIR as your doctor has prescribed: Take two 500-mg FAMVIR tablets as soon as you feel an outbreak starting. Take another two 500-mg FAMVIR tablets about 12 hours later. Start taking FAMVIR within 6 hours of either symptom onset or lesion appearance.

How can I get ready for my next outbreak?

Always be sure to have an extra supply of Single-Day FAMVIR with you. That way, you will be ready to take control of your next outbreak.

What should I do if I still have symptoms when I've finished my Single-Day FAMVIR tablets?

You only need to take Single-Day FAMVIR for one day. The medicine enters the infected cells and stays there long enough to prevent the herpes virus from reproducing. It may take a few days for you to feel better, but this does not mean you need more medicine.

Who should not use new Single-Day FAMVIR?

Anyone who is allergic to this drug or any of its contents should not use FAMVIR. (Check the FAMVIR Patient Information for a complete list of ingredients.) FAMVIR has not been studied in people under 18 years of age. Talk to your doctor if you are younger than 18 and plan to use FAMVIR. People over 65 and those who have liver or kidney problems should also talk to their doctor before using FAMVIR.

Can I use Single-Day FAMVIR if I'm pregnant?

FAMVIR is rated by the FDA as Pregnancy Category B. This means that, while studies have not been done in humans, studies with pregnant animals have shown that FAMVIR did not demonstrate any risk to the fetus in any trimester. As always, if you are pregnant or considering getting pregnant, you should discuss the risks and benefits of taking any medication with your physician. Read the FAMVIR Patient Information.

Are there any side effects with new Single-Day FAMVIR?

In clinical studies, the most common side effects in people who took Single-Day FAMVIR were headache, diarrhea, and nausea. Most side effects were mild to moderate and lasted only a short time. Talk to your doctor if side effects continue or if they bother you. For more information about other more infrequent side effects, talk to your doctor or pharmacist.

Is there another way to prevent a herpes outbreak?

Yes. Sometimes, people with recurrent genital herpes need or want suppressive therapy, which means taking medicine daily for up to 1 year to lessen the number of outbreaks. This may be because they experience many outbreaks (e.g., more than 6 per year). For many people, however, treating their genital herpes outbreak for a short period of time as soon as they feel the warning sensations (episodic treatment) is appropriate and even preferred in some cases. Fortunately, FAMVIR can be used for both episodic and suppressive treatment of genital herpes. The decision as to whether episodic or suppressive treatment is most appropriate for you should be made in consultation with your doctor. For more information, or if you feel you may need suppressive therapy with FAMVIR, please talk to your doctor.

What other important information do I need to know about new Single-Day FAMVIR?

FAMVIR is not a cure for herpes. If you are sexually active, you can still pass herpes to your partner even if you are taking FAMVIR. Herpes can be transmitted even if you do not have active symptoms.




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