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Buspirone
 
 
buspar (busirone HCL)

Buspar (buspirone) is an anti-anxiety medicine, used to reduce fear, tension and anxiety associated with anxiety disorders. Buspirone affects the chemicals in your brain that may have become unbalanced and are causing anxiety. Be sure to tell your doctor about any other medications you are taking (particularly MAOIs) to avoid potential drug interactions.

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Important Note
IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Buspirone is used to relieve nervousness, anxiety and tension.

Other Uses
Buspar may also be used for premenstrual syndrome.

How to Use
Take Buspar with food or milk if stomach upset occurs. It is important to take Buspar exactly as prescribed. Do not increase your dose or take more often than prescribed. Symptoms will begin to improve within 7 to 10 days of starting Buspar. However, it may take 3 to 4 weeks for the full benefit of the medication to be apparent.

Side Effects
Buspar may cause drowsiness, dizziness, lightheadedness, fatigue, weakness, vivid dreams, sleeplessness, dry skin, blurred vision, altered sense of taste and smell, weight gain, muscle aches, ringing in the ears, nausea, headaches. If these effects persist or worsen, notify your doctor. Notify your doctor if you experience: abnormal movements or "twitches" of the face or neck muscles, other involuntary movements or tremors, depression, confusion, incoordination, chest pain, breathing difficulties. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
Before taking buspirone, tell your doctor your medical history especially: kidney or liver disease, any drug allergies. Limit alcohol intake as it may intensify the dizziness and/or drowsiness effects of buspirone. Use caution when engaging in activities requiring alertness such as driving. Tell your doctor if you are pregnant before using this drug. It is not known if this drug is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions
Before taking buspirone tell your doctor of all over-the-counter or prescription drugs you may use especially: other drugs for anxiety or depression, MAOIs (e.g., phenelzine, tranylcypromine, isocarboxazid, selegiline, linezolid, furazolidone), azole or macrolide antibiotics, haloperidol, narcotic pain medications. Do not eat grapefruit or drink grapefruit juice unless your doctor instructs you otherwise. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, dizziness, drowsiness, and decreased pupil size.

Notes
Do not share Buspar with others.

Missed Dose
Take any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose. If more than one dose is missed, contact your doctor or pharmacist to establish a new dosing schedule.

Storage
Store at room temperature and keep away from moisture and sunlight. Do not store in the bathroom.

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Buspirone (brand-names Ansial?, Ansiced?, Anxiron?, Axoren?, Bespar?, BuSpar?, Buspimen?, Buspinol?, Buspisal?, Narol?) is an anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam[citation needed].

It shows no potential for addiction compared to other drugs commonly prescribed for anxiety, especially benzodiazepine medications. The development of tolerance has not been noticed. Cross-tolerance to benzodiazepines, barbiturates and alcohol does not exist. Furthermore, it is non-sedating.

It is thought to act by interfering with the function of the neurotransmitter serotonin in the brain, particularly by serving as a 5-HT1A receptor partial agonist. Additionally, it acts as a mixed agonist/antagonist on postsynaptic dopamine receptors. GABA-mediated effects are lacking. Buspirone may also have indirect effects on other neurotransmitters in the brain.

The action of a single dose is much longer than the short halflife of 2-3 hours indicates. The bioavailability of Buspirone is very low and variable due to extensive first pass metabolism. The drug is quickly resorbed. Taking the drug together with food may increase the bioavailabilty. The drug is highly (95%) plasma-bound. The active metabolite 1-PP is also a 5-HT1A partial agonist with anxiolytic properties, but weaker so than the mother-drug.

It is also useful as an augmenting agent, for the treatment of depression, when added to SSRIs (selective serotonin reuptake inhibitors).

The main disadvantage is that 1 to 3 weeks elapse before the anxiolytic activity becomes evident. Often patients have to be initially cotreated with a benzodiazepine for immediate anxiolysis. Generally, Buspirone works less well than benzodiazepines. It is particularly difficult to treat patients pretreated with benzodiazepines knowing the immediate effects of these tranquilizers.


 



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